GPCR-mediated signal transduction begins when an activating ligand binds and stabilizes an active conformation of the receptor that can couple to G protein. This interaction activates the G protein and initiates a cell signalling cascade based on the interaction of G protein subunits with multiple different cellular proteins. Active receptors are also phosphorylated by specific kinases, which facilitates the binding of the protein arrestin. Arrestin binding blocks further G protein-mediated signalling and, due to the prolific scaffolding ability of arrestin, mediates receptor internalization into endosomes and distinct arrestin-dependent signal transduction. Intriguingly, some ligands modulate the interaction of receptors with intracellular binding partners, such that G protein-mediated or arrestin-mediated signalling is favoured over the other pathway.Recent years have witnessed an explosion in the number of high-resolution molecular structures of different GPCRs in ligand-free and ligand-bound forms, and in complex with intracellular binding partners. These structures have already helped to elucidate the molecular details of the GPCR activation mechanism. Yet despite these advances, fundamental questions regarding GPCR function and signalling remain unanswered.
Tackling these questions will require an interdisciplinary approach that involves structural, computational, cell and systems biologists, as well as physiologists and clinicians. Here, we propose a scientific meeting that brings together GPCR researchers from these diverse fields and at different stages in their scientific careers. Although there are currently many international GPCR conferences, very few are focused on building scientific and social networks between established researchers and early-career scientists. We expect this novel approach will encourage cross-discipline cooperation and significantly advance future research. The thematic focus of the meeting is understanding how GPCRs and their associated signal transduction cascades function at the molecular, cellular and physiological level. The goal of the meeting is to bridge different fields of expertise and different levels of experience, thereby fostering the next generation of GPCR researchers.
The meeting is composed of various events, including traditional lectures and poster presentations as well as novel elements aimed at fostering networking and engaging early career scientists.
with Nobel Laureate Brian Kobilka (Stanford University) and Roger Sunahara (University of California, San Diego).
Date: Wednesday, July 11th starting at 4pm (keynote) & 6 pm (round-table)
Location: Leibniz-Saal, Markgrafenstraße 38, 10117 Berlin, Germany
Receptor meets G protein: a molecular dance that is essential for human life and drug therapy
all poster presentations will be on Thursday (P12-01 to P12-39) and Friday (P13-01 to P13-38). Please put up your posters (A0, portrait) on Thursday morning and take them off after the poster session or first thing Friday morning, so the new set of poster can be put up.
On Thursday we are going to the Kugelbahn in wedding, which is located a Grüntaler Str. 51 and is a mix of vintage venue and a ninepin bowling alley.
On Friday we are planning on going to a traditional German beer garden called Pratergarden.
Thursday to Saturday: CharitéCrossOver (CCO) at Virchowweg 6 (image below)
Suggested hotels and hostels close to the conference venue
The meeting will follow in the wake of the EU COST-funded and hugely successful GLISTEN network: GPCR-Ligand Interactions, Structures, and Transmembrane Signalling, a European Research Network. This research network already sponsored bi-annual meetings of researchers in the GPCR field, as well as training schools, workshops, and short-term scientific missions. During the four years of GLISTEN, students and post-docs played a more and more prominent role, which culminated in the formation of an Early Career Committee. The ECSF-GPCR meeting is the brainchild of the young GLISTEN members and came forth from discussions taking place at the last meetings of the network.
The meeting program is funded by the Charité Universitätsmedizin Berlin, Stiftung Charité, Berlin Institute of Health (BIH), Charité Clinical Scientist Program, FMP Leibniz-Forschungsinstitut für Pharmakologie, Collaborative Research Center CRC 1078 "Protonation Dynamics in Protein Function", GRK1910 "Medical Chemistry of Selective GPCR Ligands" and Boehringer Ingelheim Pharma.